Differin (Adapalene)


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  • Differin (Adapalene)
  • Differin (Adapalene)

Differin (Adapalene)

  • Medication features

    Differin cream is a topical treatment for acne.  It works by reducing inflammation of the skin and therefore reducing the number of blackheads, spots and acne breakouts. It also promotes healing within the skin to reduce scarring and swelling.

    • Cream used to treat acne
    • Has anti-inflammatory and healing properties


NOTE: After selecting this product, you will need to complete a short assessment, so we can make sure this medication is suitable for you. Pricing is provided as a reference only. The final decision on issuing this medication remains with our Prescriber / Pharmacist.

Differin is a gel that contains adapalene, a form of vitamin A which helps to stop pores from clogging by shrinking skin cells.


  • How long does Differin Gel take to work?

    Differin Gel starts working immediately, and results may be seen in as little as two weeks.

  • When is irritation most likely to occur?

    Skin irritation (redness, itching, dryness, burning) is more likely to occur in the first few weeks of use and/or if you use more than one topical acne product at a time.

  • If I experience skin irritation, should I discontinue use? What can I do to minimise skin irritation?

    Skin irritation is a common, temporary reaction that will usually subside after about four weeks of use. Applying it every other day, or using less of the gel can help to relieve irritation.

  • Can I stop using Differin Gel once my acne clears up?

    For best results, it’s essential to continue using Differin Gel even after skin looks clearer to help prevent future breakouts. With continued use, Differin Gel will continue to clear redness and inflammations caused by acne, prevent blackheads, and clogging of the pores.

  • Is it okay for pregnant women to use Differin Gel?

    Differin Gel is a safe and effective treatment. However, as with any medication, it’s a good idea to check with a healthcare professional if you are pregnant, planning to become pregnant or breastfeeding.

Side Effects

There is always a risk of side effects with all medications. Some of these can be quite mild and can subside over time. Others are more serious and should be reported to your GP right away if you experience any side effects. Please contact a member of our team if you are concerned about any potential side effects that may occur when taking using Differin.

Side effects may include:

  • Inflammation of the skin
  • Burning, itching, tingling, or stinging
  • Dry or flaky skin
  • Sensitivity to sunlight


Info Leaflet

Before taking any medicines, regardless of whether they are over the counter or prescription-only, it is essential always to read the patient information leaflet.

Patient Information Leaflet