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Elleste Duet

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Elleste Duet

Elleste Duet tablets are an option for hormone replacement therapy (HRT) and can help women cope and manage their menopausal symptoms such as sleeping issues, hot flushes, night sweats, and decreased libido. Elleste Duet tablets can help to alleviate symptoms and make menopause a more effortless experience. It's suitable for postmenopausal women and contains estradiol and norethisterone.

  • Reduces menopause symptoms
  • One tablet taken by mouth each day, in a 28-day sequence
  • Reduce symptoms of menopause such as hot flushes, insomnia, and night sweats

Hormone replacement therapy tablets can be oestrogen-only or can contain both oestrogen and a progestogen. Elleste Duet is a sequential combined HRT tablet. You take one tablet every day from a 28-day pack: 16 tablets containing estradiol only, followed by 12 tablets containing estradiol and norethisterone (a progestogen).

Ingredients

Elleste Duet tablets contain lactose monohydrate. The 2 mg tablets also contain sunset yellow (E110), which may cause allergic reactions. Check the patient information leaflet for the full list of ingredients.

Of course, with all forms of medications such as Elleste Duet tablets, there can be a risk of side effects. These side effects should be considered before going ahead with any form of treatment. If you are concerned about side effects from HRT tablets, you should discuss these concerns with your doctor or medical professional.

Most side effects can be mild and will go away over time. However, there are some side effects that can be difficult to manage and can affect your general health.

If you are suffering from side effects from Elleste Duet tablets, you should contact your GP or a member of our team straight away. Here are a few common side effects that can occur during treatment with Elleste Duet:

Side effects of taking Elleste Duet tablets may include:

  • Very common (more than 1 in 10 people): headache; breast pain or tenderness; painful periods; problems with your menstrual cycle
  • Common (up to 1 in 10 people): vaginal discharge; stomach cramps; increase in weight; mood changes

You will have a bleed once a month (a withdrawal bleed) while taking Elleste Duet. See your doctor as soon as possible if you have unexpected bleeding or spotting besides your monthly bleed that carries on for more than the first 6 months, starts after you have been taking Elleste Duet for more than 6 months, or carries on after you have stopped taking it.

What are the risks involved in using Elleste Duet tablets?

You should discuss concerns about risks that are involved with Elleste Duet tablets with your doctor or during your consultation. However, constant monitoring through regular checkups and following medical advice is a good way to monitor and minimise risks or complications that can occur during hormone replacement therapy.

Leaflets

Before you buy Elleste Duet tablets, regardless of whether they are over-the-counter or prescription-only, it is essential always to read the patient information leaflet.

Elleste Duet Patient Information Leaflet

Umar Razzaq, MPharm | University of Strathclyde, Clinical Pharmacist.
Content Written by:Umar RazzaqMPharm | GPhC Reg: 2064448 | University Of Strathclyde
Date Written:12/06/2026
Role:Clinical Pharmacist
Nish Fayyaz, MPharm | University of Strathclyde, Pharmacist.
Medically Reviewed By:Nish FayyazMPharm | GPhC Reg: 2225257 | University Of Strathclyde
Date Checked:12/06/2026
Role:Pharmacist
Fully inspected and regulated service
UK registered pharmacy
Approved UK-licensed treatments
Discreet next day delivery