Skip to main content
Pharmacy Online - Home
Prescription range
Spedra

Images for illustrative purposes only

Looking for Next Day delivery?

Order before 15:30 on Monday to Friday for next day delivery

Fully inspected and regulated service
UK registered pharmacy
Approved UK-licensed treatments
Discreet next day delivery

Spedra

Spedra Avanafil is one of the faster-acting treatments for erectile dysfunction. Take Spedra Avanafil in a single dose, approximately 15 to 30 minutes before sex (about 30 minutes before for the 50mg dose). It boosts blood flow to the penis, enabling an increased ability to sustain erections. It's suitable for adult males suffering from ED and contains avanafil (a PDE-5 inhibitor).

  • Take about 15 to 30 minutes before sex
  • One of the fastest-acting erectile dysfunction medications

Buy Spedra Online

Spedra erectile dysfunction treatment helps quickly achieve and maintain an erection. As one of the faster-acting erectile dysfunction treatments, Spedra tablets are taken about 15 to 30 minutes before sex.

The medication works by increasing blood flow to the penis, helping those who have difficulties gain an erection more easily. A Spedra-assisted erection is achieved following sexual arousal, meaning this medication will not give you an erection unless stimulated.

You can buy Spedra ED treatments here at Pharmacy Online, available in strengths of 50mg, 100mg, and 200mg. Start an online consultation to begin your order.

NOTE: After you buy Spedra online to treat erectile dysfunction, you will need to complete a short assessment, so we can make sure this medication is suitable for you. Pricing is provided as a reference only. The final decision on issuing this medication remains with our Prescriber / Pharmacist.

When to Use Spedra (Avanafil)?

Spedra (avanafil) is a fast-acting treatment for erectile dysfunction (ED). It's beneficial for men over 18 who are looking for a faster-acting option compared to traditional ED medicines.

Age Restrictions For Spedra

Spedra tablets are suitable for men aged 18 and over. No dose adjustment is needed for older men.

How to Use Spedra Tablets?

Please follow the instructions when using Spedra. Because it's a fast-acting medicine, it's essential to understand the importance of preparation and timing:

  • Dosage: The standard starting dose is 100mg. Depending on how well it works and how you get on with it, your prescriber might increase it to 200mg or reduce it to 50mg. If you already take an alpha-blocker, you will usually start on 50mg. If you take a moderate CYP3A4 inhibitor (see below), the maximum dose is 100mg.
  • Timing: Take 100mg or 200mg approximately 15 to 30 minutes before sexual activity, or 50mg about 30 minutes before.
  • How to Take: You can take Spedra with or without food, but if you take it with food it may take longer to start working. You should avoid heavy drinking and grapefruit juice as both can increase the risks of side effects.

When to Avoid Using Spedra Tablets?

Spedra is safe and effective in most cases, but there are some situations where you should avoid it. These include:

  • Medications: If you're currently taking nitrate medicines, use amyl nitrite ("poppers") or another nitric oxide donor, or take riociguat, you shouldn't use Spedra. You also shouldn't use it with strong CYP3A4 inhibitors: HIV medicines such as ritonavir, indinavir, saquinavir, nelfinavir or atazanavir; antifungals such as ketoconazole, itraconazole or voriconazole; the antibiotics clarithromycin or telithromycin; or nefazodone. If you take a moderate CYP3A4 inhibitor, such as erythromycin, diltiazem, fluconazole or verapamil, the maximum dose is 100mg, with at least 48 hours between doses.
  • Medical Conditions: If you've had a stroke, heart attack or life-threatening irregular heartbeat in the past six months, Spedra isn't suitable for you. The same applies if you have low blood pressure (below 90/50 mmHg), uncontrolled high blood pressure (above 170/100 mmHg), unstable angina or angina during sex, or heart failure (NYHA class 2 or above). This also applies to people with a serious cardiac problem.
  • Serious Liver or Kidney Disease: People with severe kidney or liver disease should also avoid Spedra.
  • Eye Problems: If you have ever lost sight in one eye because of NAION (non-arteritic anterior ischaemic optic neuropathy), or an inherited eye disease such as retinitis pigmentosa runs in your family, you shouldn't use Spedra.
  • Allergies: If you're allergic to avanafil or any of the other ingredients, you shouldn't use Spedra.

Precautions For Spedra

Drinking alcohol at the same time as taking Spedra may increase your heart rate and lower your blood pressure. You may feel dizzy (especially when standing), have a headache or feel your heart beating in your chest (palpitations). Drinking alcohol may also decrease your ability to get an erection.

It's also important to avoid grapefruit juice within 24 hours before taking Spedra, as it can increase the medicine's concentration in your body, which increases side effects.

Talk to your doctor or pharmacist before taking Spedra if you have ever had an erection lasting 4 hours or more, or have a condition such as sickle cell disease, multiple myeloma or leukaemia that makes this more likely; if you have a condition that affects the shape of your penis, such as angulation, Peyronie's disease or cavernosal fibrosis; or if you have a bleeding disorder or an active stomach (peptic) ulcer.

Tell your doctor if you take an alpha-blocker, for prostate problems or high blood pressure. Taking it with Spedra can lower your blood pressure, and you will usually start on the 50mg dose.

Do not use Spedra together with other treatments for erectile dysfunction, such as sildenafil, tadalafil or vardenafil.

Spedra can make you feel dizzy or affect your vision. If this happens, do not drive, cycle, or use tools or machines.

Ingredients Of Spedra

The active ingredient in Spedra is Avanafil, available in 50mg, 100mg and 200mg strengths. As a

selective phosphodiesterase type 5 (PDE5) inhibitor, it works by relaxing the blood vessels in the penis to increase blood flow during sexual stimulation.

Inactive Ingredients Include:

  • Mannitol
  • Fumaric Acid
  • Yellow Iron Oxide (E172)
  • Hydroxypropylcellulose
  • Magnesium Stearate
  • Low Substituted Hydroxypropylcellulose
  • Calcium Carbonate

Side Effects Of Spedra

Side effects can occur when taking any medication, including Spedra. Most Spedra side effects are mild and subside over time. However, some are more serious and should be reported to your GP immediately. If you are concerned about the potential side effects of Spedra, please contact a member of our team.

Common side effects of Spedra (may affect up to 1 in 10 people) can include:

  • Flushing
  • Headaches
  • Stuffy nose (nasal congestion)

Uncommon side effects of Spedra (may affect up to 1 in 100 people) can include:

  • Dizziness
  • Nausea
  • Back pain

Rare side effects of Spedra (may affect up to 1 in 1,000 people) can include:

  • Diarrhoea
  • Runny nose
  • Nosebleeds
  • Muscle aches

The side effects listed below are serious; if you notice any of them, stop taking Spedra and see a doctor straight away.

  • An erection that will not go away (priapism). If you have an erection that lasts more than 4 hours, get medical help immediately. Priapism can cause permanent damage to your penis.
  • Blurred vision.
  • Sudden vision loss in both eyes or one eye. Sudden vision loss in both eyes or one eye can be a sign of a serious eye problem called non-arteritic anterior ischemic optic neuropathy.
  • Sudden hearing decrease or hearing loss. Some men may also have ringing in their ears (tinnitus) or dizziness.
After I buy Spedra online, how long does it take to work for erectile dysfunction?

Take Spedra about 15 to 30 minutes before sex (about 30 minutes before for the 50mg dose). The time it takes to work can vary, and it may take longer to start working if you take it with food.

The effectiveness of Spedra for erectile dysfunction can depend on alcohol and food consumption. You should avoid drinking alcohol when taking Spedra, as this can reduce its effects.

How regularly can I take Spedra to treat erectile dysfunction?

Do not take Spedra more than once a day, and do not take more than one erectile dysfunction medication treatment in 24 hours.

Can I take Spedra for erectile dysfunction if I have heart problems?

If you suffer from heart problems or a heart condition, take caution and seek medical advice from a GP or an online doctor service before taking Spedra. This erectile dysfunction treatment can affect your blood pressure and put additional strain on the heart.

Whether Spedra is suitable will depend on a number of individual circumstances, including your symptoms and their severity.

Can I take Spedra even if I don’t have erectile dysfunction?

You should not take Spedra tablets unless you suffer from erectile dysfunction. It is not intended as a tablet for the purpose of sexual enhancement.

How effective is Spedra compared to other erectile dysfunction medications?

Spedra is one of the fastest-acting erectile dysfunction treatments. Viagra is slightly more effective, but it's a slower-acting ED treatment.

Spedra Patient Information Leaflet

Find out more about potential side effects, how to take Spedra and how it works in the patient information leaflet. It is essential to read the Spedra Patient Information Leaflet before taking any medicines, whether over-the-counter or prescription-only.

If you have any questions, please contact our registered pharmacists today.

Spedra Patient Information Leaflet

Umar Razzaq, MPharm | University of Strathclyde, Clinical Pharmacist.
Content Written by:Umar RazzaqMPharm | GPhC Reg: 2064448 | University Of Strathclyde
Date Written:12/06/2026
Role:Clinical Pharmacist
Nish Fayyaz, MPharm | University of Strathclyde, Pharmacist.
Medically Reviewed By:Nish FayyazMPharm | GPhC Reg: 2225257 | University Of Strathclyde
Date Checked:12/06/2026
Role:Pharmacist
Fully inspected and regulated service
UK registered pharmacy
Approved UK-licensed treatments
Discreet next day delivery