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  • Atovaquone/Proguanil


  • Medication features

    Atovaquone/Proguanil is a tablet that is used to prevent malaria. It belongs to the family of medicines called antimalarials. It has two active ingredients: atovaquone and proguanil. Both work in combination to kill the parasite P. falciparum, which is known to cause malaria.

    • Used to prevent malaria infection
    • Kills the parasite responsible for malaria
    • Cheaper generic version of Malarone


NOTE: After selecting this product, you will need to complete a short assessment, so we can make sure this medication is suitable for you. Pricing is provided as a reference only. The final decision on issuing this medication remains with our Prescriber / Pharmacist.

Atovaquone/Proguanil, sold under the brand name Malarone, is used for malaria prevention in individuals travelling to high-risk countries.


One tablet to be taken daily, started 1-2 days before travelling, continued for seven days after returning from an at-risk country.


  • Is Atovaquone/Proguanil (Malarone) suitable for my trip?

    Malaria is caused by four different strains of malaria parasite. The various treatment options are based on which strain is the most common in the area that you intend to travel to.

    To help you make sure that you chose the right medication for your trip, visit the government Fit For Travel website for the most up to date travel information.

  • How do I take Atovaquone/Proguanil (Malarone)?

    The course should be started one to two days before you travel, and taken for the full length of time that you are in the malaria zone. You should also continue the course for a further seven days.

    It is important to continue to take Atovaquone/Proguanil (Malarone) for seven days after leaving the malaria zone to ensure the parasites from an infected bite are killed.

  • What do I do if I miss a dose?

    If you miss a dose, you should take a tablet as soon as you remember. You should not take more than one tablet a day; if too much time has elapsed since your last dose, continue as before taking one tablet a day.

  • What if I am sick whilst taking Atovaquone/Proguanil (Malarone)?

    If you are sick within one hour of taking your tablet, you will need to take a replacement tablet to ensure that you are adequately protected. You should then continue taking your course as normal.

  • Can I drink alcohol whilst taking Atovaquone/Proguanil (Malarone)?

    You can drink alcohol; however, one of the possible side effects associated with Atovaquone/Proguanil (Malarone) is dizziness; if you experience this, avoid drinking alcohol as it may make your dizziness worse.

Side Effects

There is always a risk of side effects with all medications. Some of these can be quite mild and can subside over time. Others are more serious and should be reported to your GP right away if you experience any side effects. Please contact a member of our team if you are concerned about any potential side effects that may occur when taking atovaquone/proguanil.

Common side effects may include:

  • Sleep disturbances
  • Nausea
  • Dizziness
  • Diarrhoea
  • Abdominal pain
  • Decreased appetite
  • Fever
  • Headache
  • Vomiting
  • Skin reactions

This medication can sometimes cause skin rash and blisters. It may result in peeling skin, especially around the mouth. If you develop a rash, you need to seek medical help immediately.